Preparation, in vitro and in vivo evaluation of solid-in-oil dispersion-based formulation the anti-glaucoma drug, timolol maleate

Lowering Intraocular pressure (IOP) is a main therapeutic objective in glaucoma patients because IOP an important risk factor for progression. The of this work was to formulate and evaluate, vitro vivo, stable effective Solid Oil (S/O) topical formulation the antiglaucoma drug, timolol maleate (TM). S/O dispersions were prepared by emulsification aqueous TM solutions cyclohexane using different amount span 85 then lyophilizing emulsion produce – Span complexes. complexes dispersed castor oil tip sonicator nanodispersions. nanodispersions evaluated terms particle size, polydispersity index, encapsulation efficiency, morphology, physical stability, as well transcorneal permeation accumulation TM. In addition, vivo tolerability efficacy lowering intraocular rabbits.
 Spherical nanoparticles with size about 134-155 nm successfully found be physically stable. efficiency high dependent on level used.
 comparison solution, nanodispersion enhanced decreased diffusion studies. application onto rabbit eyes resulted significant reduction solution.